Interpreting Your DNA Test Results…
There are three possible test results: Clear, Carrier, and
Affected. Below is a description of what each result means to you as a
CLEAR This finding
indicates that the gene is not present in your dog. Therefore, when used for
breeding, a Clear dog will not pass on the disease gene.
CARRIER This finding
indicates that one copy of the disease gene is present in your dog, but that
it will not exhibit disease symptoms. Carriers will not have medical
problems as a result. Dogs with Carrier status can be enjoyed without the
fear of developing medical problems but will pass on the disease gene 50% of
AFFECTED This finding
indicates that two copies of the disease gene are present in the dog.
Unfortunately, the dog will be medically affected by the disease.
Appropriate treatment should be pursued by consulting a
VetGen's DNA test findings can be extremely valuable when
developing and implementing your breeding plans. The chart provided below
outlines the implications of various breeding pair combinations. Remember,
it is always best to breed "Clear to Clear". If followed by all breeders,
these strategies will ensure a significant reduction in the frequency of the
targeted disease gene in future generations of dogs. However, to maintain a
large enough pool of good breeding stock, it may be necessary for some
breeders to breed "Clear" to "Carriers" (see below).
Ideal Breeding Pair. Puppies
will not have the disease gene (neither as Carrier nor as Affected).
Breeding Is Safe. No Affected
puppies will be produced. However, some or all puppies will be Carriers.
Accordingly, it is recommended that Carrier dogs which are desirable for
breeding be bred with Clear dogs in the future, which will produce 50%
carrier and 50% clear animals, to further reduce the disease gene frequency.
These offspring should be tested by VetGen's test for this defective gene,
and if possible, only the clear animals in this generation should be
High Risk Breeding. Some puppies
are likely to be Carriers and some puppies are likely to be Affected. Even
though it is possible that there will be some clear puppies when breeding
"Carrier to Carrier", in general, neither this type of breeding pair nor
"Carrier to Affected" are recommended for breeding.
Breeding Not Recommended. All puppies will be medically Affected.
Canine: vWD Patents